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KMID : 1039120170060020120
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Clinical and Experimental Vaccine Research
2017 Volume.6 No. 2 p.120 ~ p.127
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Static model simulation for routine mumps vaccination in Japan: with a result of mumps-related complications in a Japanese community hospital
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Kitano Taito
Onaka Masayuki
Ishihara Mariko
Nishiyama Atsuko
Hashimoto Naoki
Yoshida Sayaka
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Abstract
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Purpose: Mumps vaccine has not been included in the routine national immunization program in Japan, leading to low vaccine coverage rates and periodic epidemics approximately every 5 years. Our hospital (a secondary community hospital in Japan) experienced an increased number of mumps-related complications with a nationwide epidemic in 2016. Using previously reported data and mumps-related cases in our hospital, we estimated the cost-effectiveness of routine mumps vaccination in Japan with a static model using current epidemiologic data.
Materials and Methods: With a decision tree flowchart of mumps infection and adverse events, we estimated the burden of mumps-related complications in our hospital for 5 years, and calculated the current annual national burden. Finally, we compared the current burden and assumptive burden of the stable state after routine vaccination in Japan using a static model.
Results: The cost-benefit ratios with sensitivity analysis were 3.69 (1.08-9.52) and 6.84 (1.51-23.73) in independent inoculation and simultaneous inoculation, respectively, from a social perspective in addition to an annual gain of 9,487 (3,227-14,659) quality adjusted life years.
Conclusion: We contributed additional evidence in terms of cost-effectiveness that routine mumps vaccination should be introduced in Japan with simultaneous inoculation.
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KEYWORD
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Mumps vaccine, Immunization program, Cost-benefit analysis, Quality adjusted life years
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